A thiol-ester in α2 -macroglobulin cleaved during proteinase complex formation
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چکیده
منابع مشابه
Metabolism of the Complex Monofluorophosphate-α2-macroglobulin in the Rat
Sodium monofluorophosphate (MFP) is a drug used in the treatment of primary osteoporosis. Following the intake of MFP, a small fraction of the drug is absorbed intact and forms a complex with α2-macroglobulin (MFP-α2M) inactivating the antiproteasic activity of the globulin. The complex has been shown to occur in the serum of rats and human being. This paper reports data on the metabolism of th...
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Intra-chain thiol ester bonds are present in a limited number of proteins. The thiol ester class of proteins includes vertebrate alpha 2-macroglobulin and the complement proteins C3 and C4. We report here the first instance of a thiol ester protein from an invertebrate, the alpha 2-macroglobulin proteinase-inhibitor homologue present in the plasma of the American horseshoe crab Limulus polyphem...
متن کاملsimulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water
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Studies on Human Plasma Α2-macroglobulin-enzyme Interactions
Human plasma alpha(2)-macroglobulin is an inhibitor of circulating proteases that function in hemostatic and inflammatory reactions but the biochemical nature of its interaction with these enzymes is not well defined. This investigation has found that alpha(2)-macroglobulin is comprised of subunit chains of 185,000 molecular weight as analyzed by electrophoresis in polyacrylamide gels containin...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1980
ISSN: 0014-5793
DOI: 10.1016/0014-5793(80)80361-9